Open AccessSimulation study on compressive laminar optical tomography for cardiac action potential propagation
Author(s) -
Takeo Harada,
Naoki Tomii,
Shota Manago,
Etsuko Kobayashi,
Ichiro Sakuma
Publication year - 2017
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.8.002339
Subject(s) - laminar flow , digital micromirror device , tomography , optics , optical tomography , iterative reconstruction , diffuse optical imaging , computer science , biomedical engineering , optical mapping , compressed sensing , frame rate , materials science , computer vision , artificial intelligence , physics , medicine , thermodynamics
To measure the activity of tissue at the microscopic level, laminar optical tomography (LOT), which is a microscopic form of diffuse optical tomography, has been developed. However, obtaining sufficient recording speed to determine rapidly changing dynamic activity remains major challenges. For a high frame rate of the reconstructed data, we here propose a new LOT method using compressed sensing theory, called compressive laminar optical tomography (CLOT), in which novel digital micromirror device-based illumination and data reduction in a single reconstruction are applied. In the simulation experiments, the reconstructed volumetric images of the action potentials that were acquired from 5 measured images with random pattern featured a wave border at least to a depth of 2.5 mm. Consequently, it was shown that CLOT has potential for over 200 fps required for the cardiac electrophysiological phenomena.