Open AccessIn vivo pentamodal tomographic imaging for small animals
Author(s) -
Muhan Liu,
Hongbo Guo,
Hongbo Liu,
Zeyu Zhang,
Chongwei Chi,
Hui Hui,
Di Dong,
Zhenhua Hu,
Hui Hui
Publication year - 2017
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.8.001356
Subject(s) - molecular imaging , positron emission tomography , preclinical imaging , tomography , tomographic reconstruction , medical physics , medical imaging , computed tomography laser mammography , multimodality , bioluminescence imaging , in vivo , fluorescence lifetime imaging microscopy , biomedical engineering , nuclear medicine , radiology , medicine , computer science , optics , fluorescence , physics , chemistry , biology , luciferase , transfection , biochemistry , microbiology and biotechnology , world wide web , gene
Multimodality molecular imaging emerges as a powerful strategy for correlating multimodal information. We developed a pentamodal imaging system which can perform positron emission tomography, bioluminescence tomography, fluorescence molecular tomography, Cerenkov luminescence tomography and X-ray computed tomography successively. Performance of sub-systems corresponding to different modalities were characterized. In vivo multimodal imaging of an orthotopic hepatocellular carcinoma xenograft mouse model was performed, and acquired multimodal images were fused. The feasibility of pentamodal tomographic imaging system was successfully validated with the imaging application on the mouse model. The ability of integrating anatomical, metabolic, and pharmacokinetic information promises applications of multimodality molecular imaging in precise medicine.