Heart structural remodeling in a mouse model of Duchenne cardiomyopathy revealed using optical polarization tractography [Invited] | Zendy

Y. Wang | Zendy; K. Zhang | Zendy; Dongsheng Duan | Zendy; Gang Yao | Zendy

Open Access

Heart structural remodeling in a mouse model of Duchenne cardiomyopathy revealed using optical polarization tractography [Invited]

Author(s) -

Y. Wang,

K. Zhang,

Dongsheng Duan,

Gang Yao

Publication year - 2017

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.8.001271

Subject(s) - ventricle , tractography , cardiomyopathy , cardiology , medicine , heart failure , myocyte , diffusion mri , anatomy , magnetic resonance imaging , radiology

We investigated the heart structural remodeling in the mdx4cv mouse model of Duchenne cardiomyopathy using optical polarization tractography. Whole heart tractography was obtained in freshly dissected hearts from six mdx4cv mice. Six hearts from C57BL/6J mice were also imaged as the normal control. The mdx4cv hearts were significantly larger than the control hearts and had significantly higher between-subject variations in myofiber organization. While both strains showed classic cross-helical fiber organization in the left ventricle, the rate of the myocardial fiber orientation change across the heart wall was significantly altered in the right ventricle of the mdx4cv heart.

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