Open AccessFully integrated optical coherence tomography, ultrasound, and indocyanine green-based fluorescence tri-modality system for intravascular imaging
Author(s) -
Yan Li,
Joseph Jing,
Yueqiao Qu,
Yusi Miao,
Buyun Zhang,
Teng Ma,
Mingyue Yu,
Qifa Zhou,
Zhongping Chen
Publication year - 2017
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.8.001036
Subject(s) - indocyanine green , optical coherence tomography , fluorescence lifetime imaging microscopy , modality (human–computer interaction) , ultrasound , biomedical engineering , diffuse optical imaging , preclinical imaging , medicine , radiology , medical imaging , tomography , nuclear medicine , fluorescence , pathology , optics , computer science , artificial intelligence , in vivo , physics , microbiology and biotechnology , biology
We present a tri-modality imaging system and fully integrated tri-modality probe for intravascular imaging. The tri-modality imaging system is able to simultaneously acquire optical coherence tomography (OCT), ultrasound (US), and fluorescence imaging. Moreover, for fluorescence imaging, we used the FDA-approved indocyanine green (ICG) dye as the contrast agent to target lipid-loaded macrophages. We conducted imaging from a male New Zealand white rabbit to evaluate the performance of the tri-modality system. In addition, tri-modality images of rabbit aortas were correlated with hematoxylin and eosin (H&E) histology to check the measurement accuracy. The fully integrated miniature tri-modality probe, together with the use of ICG dye suggest that the system is of great potential for providing a more accurate assessment of vulnerable plaques in clinical applications.