Multifrequency-swept optical coherence microscopy for highspeed full-field tomographic vibrometry in biological tissues | Zendy

Samuel Choi | Zendy; Keita Sato | Zendy; T. Ōta | Zendy; Fumiaki Nin | Zendy; Shogo Muramatsu | Zendy; Hiroshi Hibino | Zendy

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Multifrequency-swept optical coherence microscopy for highspeed full-field tomographic vibrometry in biological tissues

Author(s) -

Samuel Choi,

Keita Sato,

T. Ōta,

Fumiaki Nin,

Shogo Muramatsu,

Hiroshi Hibino

Publication year - 2017

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.8.000608

Subject(s) - optical coherence tomography , optics , coherence (philosophical gambling strategy) , laser doppler velocimetry , microscopy , doppler effect , heterodyne (poetry) , tomographic reconstruction , tomography , physics , materials science , acoustics , medicine , blood flow , quantum mechanics , astronomy

Because conventional laser Doppler vibrometry or Doppler optical coherence tomography require mechanical scanning probes that cannot simultaneously measure the wide-range dynamics of bio-tissues, a multifrequency-swept optical coherence microscopy with wide-field heterodyne detection technique was developed. A 1024 × 1024 × 2000 voxel volume was acquired with an axial resolution of ~1.8 μm and an acquisition speed of 2 s. Vibration measurements at 10 kHz were performed over a wide field of view. Wide-field tomographic vibration measurements of a mouse tympanic membrane are demonstrated to illustrate the applicability of this method to live animals.

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