In-vivo monitoring of tissue oxygen saturation in deep brain structures using a single fiber optical system | Zendy

Linhui Yu | Zendy; Ying Wu | Zendy; Jeff F. Dunn | Zendy; Kartikeya Murari | Zendy

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In-vivo monitoring of tissue oxygen saturation in deep brain structures using a single fiber optical system

Author(s) -

Linhui Yu,

Ying Wu,

Jeff F. Dunn,

Kartikeya Murari

Publication year - 2016

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.7.004685

Subject(s) - imaging phantom , optical fiber , materials science , brain tissue , biomedical engineering , monte carlo method , diffuse reflectance infrared fourier transform , optics , fiber optic sensor , diffuse reflection , fluorescence , fiber , mean squared error , oxygen , wavelength , optoelectronics , chemistry , physics , medicine , biochemistry , statistics , mathematics , organic chemistry , composite material , photocatalysis , catalysis

We propose a single fiber optical system for monitoring tissue oxygen saturation ( sO 2 ) based on continuous-wave reflectance spectroscopy in the visible wavelengths. The system is designed for measurements in deep brain structures by stereotaxically implanting the 200 μ m-core fiber probe into the tissue of interest. Monte Carlo (MC) simulations were used to estimate the measurement tissue volume between 0.02-0.03 mm 3 . Experiments in an optical phantom indicated the system had a root mean squared error (RMSE) of 4.21% compared with a commercial fluorescence-based tissue oxygen partial pressure measuring system. Finally, we used the system for continuously monitoring tissue sO 2 from a highly-localized volume in anesthetized mice.

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