Open AccessIn-vivo monitoring of tissue oxygen saturation in deep brain structures using a single fiber optical system
Author(s) -
Linhui Yu,
Ying Wu,
Jeff F. Dunn,
Kartikeya Murari
Publication year - 2016
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.7.004685
Subject(s) - imaging phantom , optical fiber , materials science , brain tissue , biomedical engineering , optics , monte carlo method , diffuse reflectance infrared fourier transform , fiber optic sensor , diffuse reflection , fiber , fluorescence , oxygen , mean squared error , chemistry , physics , medicine , biochemistry , statistics , mathematics , organic chemistry , composite material , photocatalysis , catalysis
We propose a single fiber optical system for monitoring tissue oxygen saturation ( sO 2 ) based on continuous-wave reflectance spectroscopy in the visible wavelengths. The system is designed for measurements in deep brain structures by stereotaxically implanting the 200 μ m-core fiber probe into the tissue of interest. Monte Carlo (MC) simulations were used to estimate the measurement tissue volume between 0.02-0.03 mm 3 . Experiments in an optical phantom indicated the system had a root mean squared error (RMSE) of 4.21% compared with a commercial fluorescence-based tissue oxygen partial pressure measuring system. Finally, we used the system for continuously monitoring tissue sO 2 from a highly-localized volume in anesthetized mice.