Open AccessFunctional imaging of the human brain using a modular, fibre-less, high-density diffuse optical tomography system
Author(s) -
Danial Chitnis,
Robert J. Cooper,
Laurie A Dempsey,
Samuel Powell,
Simone Quaggia,
David Highton,
Clare E. Elwell,
Jeremy C. Hebden,
Nick Everdell
Publication year - 2016
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.7.004275
Subject(s) - diffuse optical imaging , neuroimaging , biomedical engineering , tomography , modular design , optical tomography , image quality , computer science , optics , materials science , physics , computer vision , medicine , image (mathematics) , operating system , psychiatry
We present the first three-dimensional, functional images of the human brain to be obtained using a fibre-less, high-density diffuse optical tomography system. Our technology consists of independent, miniaturized, silicone-encapsulated DOT modules that can be placed directly on the scalp. Four of these modules were arranged to provide up to 128, dual-wavelength measurement channels over a scalp area of approximately 60 × 65 mm 2 . Using a series of motor-cortex stimulation experiments, we demonstrate that this system can obtain high-quality, continuous-wave measurements at source-detector separations ranging from 14 to 55 mm in adults, in the presence of hair. We identify robust haemodynamic response functions in 5 out of 5 subjects, and present diffuse optical tomography images that depict functional haemodynamic responses that are well-localized in all three dimensions at both the individual and group levels. This prototype modular system paves the way for a new generation of wearable, wireless, high-density optical neuroimaging technologies.