Open AccessProcedures for risk-stratification of lung cancer using buccal nanocytology
Author(s) -
Hariharan Subramanian,
Parvathi Viswanathan,
Lusik Cherkezyan,
Radha Iyengar,
Sergey Rozhok,
Michael Verleye,
Justin Derbas,
Jerry Czarnecki,
Hemant K. Roy,
Vadim Backman
Publication year - 2016
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.7.003795
Subject(s) - standardization , lung cancer , buccal administration , medicine , buccal swab , medical physics , stage (stratigraphy) , risk stratification , clinical practice , cancer , computer science , pathology , risk analysis (engineering) , dentistry , family medicine , paleontology , biology , genetics , operating system
Lung cancer is the leading cause of cancer deaths in the U.S. with survival dramatically depending on stage at diagnosis. We had earlier reported that nanocytology of buccal cells can accurately risk-stratify smokers for the presence of early and late-stage lung cancer. To translate the technique into clinical practice, standardization of operating procedures is necessary to consistently yield precise and repeatable results. Here, we develop and validate simple, robust, and easily implementable procedures for specimen collection, processing, etc. in addition to a commercially-viable instrument prototype. Results of this work enable translation of the technology from academic lab to physicians' office.