Open AccessCombined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging
Author(s) -
Mengyang Li,
Zhe Chen,
Behrooz Zabihian,
Christoph Sinz,
Edward Zhang,
Paul C. Beard,
Laurin Ginner,
Erich Hoover,
Micheal Minneman,
Rainer A. Leitgeb,
Harald Kittler,
Wolfgang Drexler
Publication year - 2016
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.7.003390
Subject(s) - optical coherence tomography , preclinical imaging , photoacoustic imaging in biomedicine , angiography , in vivo , tomography , medicine , biomedical engineering , optical coherence tomography angiography , radiology , optics , biology , physics , microbiology and biotechnology
Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an articulated probe to extract human cutaneous vasculature in vivo in various skin regions. OCT angiography supplements the microvasculature which PAT alone is unable to provide. Co-registered volumes for vessel network is further embedded in the morphologic image provided by OCT. This multi-modal system is therefore demonstrated as a valuable tool for comprehensive non-invasive human skin vasculature and morphology imaging in vivo .