Open AccessSplit-spectrum phase-gradient optical coherence tomography angiography
Author(s) -
Gangjun Liu,
Yali Jia,
Alex D. Pechauer,
Rahul Chandwani,
David Huang
Publication year - 2016
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.7.002943
Subject(s) - optical coherence tomography , optics , angiography , phase (matter) , materials science , coherence (philosophical gambling strategy) , jitter , biomedical engineering , physics , computer science , radiology , medicine , telecommunications , quantum mechanics
A phase gradient angiography (PGA) method is proposed for optical coherence tomography (OCT). This method allows the use of phase information to map the microvasculature in tissue without the correction of bulk motion and laser trigger jitter induced phase artifacts. PGA can also be combined with the amplitude/intensity to improve the performance. Split-spectrum technique can further increase the signal to noise ratio by more than two times. In-vivo imaging of human retinal circulation is shown with a 70 kHz, 840 nm spectral domain OCT system and a 200 kHz, 1050 nm swept source OCT system. Four different OCT angiography methods are compared. The best performance was achieved with split-spectrum amplitude and phase-gradient angiography.