Optically controlled release of DNA based on nonradiative relaxation process of quenchers | Zendy

Yusuke Ogura | Zendy; Atsushi Onishi | Zendy; Takahiro Nishimura | Zendy; Jun Tanida | Zendy

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Optically controlled release of DNA based on nonradiative relaxation process of quenchers

Author(s) -

Yusuke Ogura,

Atsushi Onishi,

Takahiro Nishimura,

Jun Tanida

Publication year - 2016

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.7.002142

Subject(s) - fluorescence , relaxation (psychology) , dna , excitation , chemistry , photochemistry , substrate (aquarium) , biophysics , optoelectronics , materials science , optics , physics , psychology , social psychology , biochemistry , oceanography , quantum mechanics , biology , geology

Optically controlled release of a DNA strand based on a nonradiative relaxation process of black hole quenchers (BHQs), which are a sort of dark quenchers, is presented. BHQs act as efficient energy sources because they relax completely via a nonradiative process, i.e., without fluorescent emission-based energy losses. A DNA strand is modified with BHQs and the release of its complementary strand is controlled by excitation of the BHQs. Experimental results showed that up to 50% of the target strands were released, and these strands were capable of inducing subsequent reactions. The controlled release was localized on a substrate within an area of no more than 5 micrometers in diameter.

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