Open AccessTemperature feedback-controlled photothermal treatment with diffusing applicator: theoretical and experimental evaluations
Author(s) -
Trung Hau Nguyen,
Suhyun Park,
Kyu Kyu Hlaing,
Hyun Wook Kang
Publication year - 2016
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.7.001932
Subject(s) - photothermal therapy , pid controller , materials science , diffuser (optics) , irradiation , time constant , photothermal effect , thermal , biomedical engineering , optics , temperature control , nanotechnology , thermodynamics , physics , medicine , light source , electrical engineering , engineering , nuclear physics
To minimize thermal injury, the current study evaluated the real-time temperature monitoring with a proportional-integrative-derivative (PID) controller during 980-nm photothermal treatment with a radially-diffusing applicator. Both simulations and experiments demonstrated comparable thermal behaviors in temperature distribution and the degree of irreversible tissue denaturation. The PID-controlled application constantly maintained the pre-determined temperature of 353 K (steady-state error = < 1 K). Due to constant energy delivery, coagulation volumes linearly increased up to 1.04 ± 0.02 cm(3) with irradiation time. Integration of temperature feedback with diffuser-assisted photothermal treatments can provide a feasible therapeutic modality to treat pancreatic tumors in an effective manner.