Erythrocyte-derived nano-probes functionalized with antibodies for targeted near infrared fluorescence imaging of cancer cells | Zendy

Jenny T. Mac | Zendy; Vicente Nuñez | Zendy; Joshua M. Burns | Zendy; Yadir Guerrero | Zendy; Valentine I. Vullev | Zendy; Bahman Anvari | Zendy

Open Access

Erythrocyte-derived nano-probes functionalized with antibodies for targeted near infrared fluorescence imaging of cancer cells

Author(s) -

Jenny T. Mac,

Vicente Nuñez,

Joshua M. Burns,

Yadir Guerrero,

Valentine I. Vullev,

Bahman Anvari

Publication year - 2016

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.7.001311

Subject(s) - fluorescence , fluorescence lifetime imaging microscopy , nano , materials science , cancer , optics , nanotechnology , biophysics , pathology , medicine , biology , physics , composite material

Constructs derived from mammalian cells are emerging as a new generation of nano-scale platforms for clinical imaging applications. Herein, we report successful engineering of hybrid nano-structures composed of erythrocyte-derived membranes doped with FDA-approved near infrared (NIR) chromophore, indocyanine green (ICG), and surface-functionalized with antibodies to achieve molecular targeting. We demonstrate that these constructs can be used for targeted imaging of cancer cells in vitro. These erythrocyte-derived optical nano-probes may provide a potential platform for clinical translation, and enable molecular imaging of cancer biomarkers.

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