Open AccessErythrocyte-derived nano-probes functionalized with antibodies for targeted near infrared fluorescence imaging of cancer cells
Author(s) -
Jenny T. Mac,
Vicente Nuñez,
Joshua M. Burns,
Yadir Guerrero,
Valentine I. Vullev,
Bahman Anvari
Publication year - 2016
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.7.001311
Subject(s) - indocyanine green , molecular imaging , nanotechnology , fluorescence lifetime imaging microscopy , fluorescence , cancer cell , materials science , hyperspectral imaging , cancer , chromophore , biophysics , biomedical engineering , chemistry , medicine , pathology , optics , biology , computer science , in vivo , organic chemistry , physics , microbiology and biotechnology , artificial intelligence
Constructs derived from mammalian cells are emerging as a new generation of nano-scale platforms for clinical imaging applications. Herein, we report successful engineering of hybrid nano-structures composed of erythrocyte-derived membranes doped with FDA-approved near infrared (NIR) chromophore, indocyanine green (ICG), and surface-functionalized with antibodies to achieve molecular targeting. We demonstrate that these constructs can be used for targeted imaging of cancer cells in vitro. These erythrocyte-derived optical nano-probes may provide a potential platform for clinical translation, and enable molecular imaging of cancer biomarkers.