Open AccessQuantitative optical coherence elastography based on fiber-optic probe for in situ measurement of tissue mechanical properties
Author(s) -
Yi Qiu,
Yahui Wang,
Yiqing Xu,
Namas Chandra,
James Haorah,
Basil Hubbi,
Bryan J. Pfister,
Xuan Li
Publication year - 2016
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.7.000688
Subject(s) - elastography , optical coherence tomography , materials science , optical fiber , biomedical engineering , optics , interferometry , biological tissue , elasticity (physics) , biomechanics , acoustic radiation force , acoustics , ultrasound , physics , composite material , anatomy , medicine
We developed a miniature quantitative optical coherence elastography (qOCE) instrument with an integrated Fabry-Perot force sensor, for in situ elasticity measurement of biological tissue. The technique has great potential for biomechanics modeling and clinical diagnosis. We designed the fiber-optic qOCE probe that was used to exert a compressive force to deform tissue at the tip of the probe. Using the space-division multiplexed optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to quantify the probe deformation that was proportional to the force applied, and to quantify the tissue deformation corresponding to the external stimulus. Simultaneous measurement of force and displacement allowed us to extract Young's modulus of biological tissue. We experimentally calibrated our qOCE instrument, and validated its effectiveness on tissue mimicking phantoms and biological tissues.