Open AccessLock-in-photon-counting-based highly-sensitive and large-dynamic imaging system for continuous-wave diffuse optical tomography
Author(s) -
Weiting Chen,
Xin Wang,
Bingyuan Wang,
Yihan Wang,
Yanqi Zhang,
Huijuan Zhao,
Feng Gao
Publication year - 2016
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.7.000499
Subject(s) - photon counting , diffuse optical imaging , imaging phantom , detector , computer science , optics , robustness (evolution) , optical coherence tomography , dynamic range , linearity , photon , tomography , physics , biochemistry , chemistry , quantum mechanics , gene
We implemented a novel lock-in photon-counting detection architecture that combines the ultra-high sensitivity of the photon-counting detection and the measurement parallelism of the lock-in technique. Based on this technique, a dual-wavelength simultaneous measurement continuous wave diffuse optical tomography system was developed with a configuration of 16 sources and 16 detectors that works in a tandem serial-to-parallel fashion. Methodology validation and performance assessment of the system were conducted using phantom experiments that demonstrate excellent measurement linearity, moderate-term system stability, robustness to noise and negligible inter-wavelength crosstalk. 2-D imaging experiments further validate high sensitivity of the lock-in photon-counting methodology as well as high reliability of the proposed system. The advanced detection principle can be adapted to achieving a fully parallelized instrumentation for the extended applications.