Light controlled drug delivery containers based on spiropyran doped liquid crystal micro spheres | Zendy

Gia Petriashvili | Zendy; Lali Devadze | Zendy; Tsisana Zurabishvili | Zendy; Eka Sepashvili | Zendy; Ketevan Chubinidze | Zendy

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Light controlled drug delivery containers based on spiropyran doped liquid crystal micro spheres

Author(s) -

Gia Petriashvili,

Lali Devadze,

Tsisana Zurabishvili,

Eka Sepashvili,

Ketevan Chubinidze

Publication year - 2016

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.7.000442

Subject(s) - spiropyran , drug delivery , materials science , doping , liquid crystal , nanotechnology , spheres , optics , optoelectronics , photochromism , physics , astronomy

We have developed a novel, light activated drug delivery containers, based on spiropyran doped liquid crystal micro spheres. Upon exposure to UV/violet light, the spiropyran molecules entrapped inside the nematic liquid crystal micro spheres, interconvert from the hydrophobic, oil soluble form, to the hydrophilic, water soluble merocyanine one, which stimulates the translocation of the merocyanine molecules across the nematic liquid crystal-water barrier and results their homogeneous distribution throughout in an aqueous environment. Light controllable switching property and extremely high solubility of spiropyran in the nematic liquid crystal, promise to elaborate a novel and reliable vehicles for the drug delivery systems.

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