Open AccessIn vivo burn diagnosis by camera-phone diffuse reflectance laser speckle detection
Author(s) -
Sigal Ragol,
Itay Remer,
Yaron Shoham,
S. Hazan,
Udi Willenz,
Igor Sinelnikov,
V. V. Dronov,
Lior Rosenberg,
A. Bilenca
Publication year - 2015
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.7.000225
Subject(s) - speckle pattern , diffuse reflection , optics , laser , materials science , speckle imaging , diffuse reflectance infrared fourier transform , biomedical engineering , medicine , physics , chemistry , biochemistry , photocatalysis , catalysis
Burn diagnosis using laser speckle light typically employs widefield illumination of the burn region to produce two-dimensional speckle patterns from light backscattered from the entire irradiated tissue volume. Analysis of speckle contrast in these time-integrated patterns can then provide information on burn severity. Here, by contrast, we use point illumination to generate diffuse reflectance laser speckle patterns of the burn. By examining spatiotemporal fluctuations in these time-integrated patterns along the radial direction from the incident point beam, we show the ability to distinguish partial-thickness burns in a porcine model in vivo within the first 24 hours post-burn. Furthermore, our findings suggest that time-integrated diffuse reflectance laser speckle can be useful for monitoring burn healing over time post-burn. Unlike conventional diffuse reflectance laser speckle detection systems that utilize scientific or industrial-grade cameras, our system is designed with a camera-phone, demonstrating the potential for burn diagnosis with a simple imager.