Open AccessPhase contrast x-ray velocimetry of small animal lungs: optimising imaging rates
Author(s) -
Rhian P. Murrie,
David M. Paganin,
Andreas Fouras,
Kaye S. Morgan
Publication year - 2015
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.7.000079
Subject(s) - velocimetry , population , preclinical imaging , phase contrast microscopy , phase contrast imaging , biomedical engineering , optics , medicine , physics , in vivo , biology , microbiology and biotechnology , environmental health
Chronic lung diseases affect a vast portion of the world's population. One of the key difficulties in accurately diagnosing and treating chronic lung disease is our inability to measure dynamic motion of the lungs in vivo. Phase contrast x-ray imaging (PCXI) allows us to image the lungs in high resolution by exploiting the difference in refractive indices between tissue and air. Combining PCXI with x-ray velocimetry (XV) allows us to track the local motion of the lungs, improving our ability to locate small regions of disease under natural ventilation conditions. Via simulation, we investigate the optimal imaging speed and sequence to capture lung motion in vivo in small animals using XV on both synchrotron and laboratory x-ray sources, balancing the noise inherent in a short exposure with motion blur that results from a long exposure.