Open AccessDifferentiation of cutaneous melanoma from surrounding skin using laser-induced breakdown spectroscopy
Author(s) -
Jung Yeol Han,
Young-Hyun Moon,
Dong Kun Lee,
Si Hwan Choi,
Yong-Chul Kim,
Sungho Jeong
Publication year - 2015
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.7.000057
Subject(s) - laser induced breakdown spectroscopy , melanoma , dermis , elemental analysis , principal component analysis , pathology , materials science , biomedical engineering , linear discriminant analysis , laser , medicine , chemistry , optics , cancer research , computer science , physics , organic chemistry , artificial intelligence
Laser-induced breakdown spectroscopy (LIBS) has the potential to be used as a surgical tool for simultaneous tissue ablation and elemental analysis of the ablated tissue. LIBS may be used to distinguish melanoma lesions from the surrounding dermis based on the quantitative difference of elements within melanoma lesions. Here, we measured the elements in homogenized pellets and real tissues from excised skin samples of melanoma-implanted mice. In addition, statistical analysis of LIBS spectra using principal component analysis and linear discriminant analysis was performed. Our results showed that this method had high detection sensitivity, highlighting the potential of this tool in clinical applications.