Open AccessLaser speckle imaging of intra organ drug distribution
Author(s) -
Dmitry D. Postnov,
NielsHenrik HolsteinRathlou,
Olga Sosnovtseva
Publication year - 2015
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.6.005055
Subject(s) - blood flow , speckle pattern , distribution (mathematics) , laser doppler velocimetry , kidney , speckle imaging , medicine , laminar flow , pathology , biomedical engineering , optics , physics , mathematical analysis , mathematics , thermodynamics
Laminar flow in arteries causes streaming and uneven distribution of infused agents within the organ. This may lead to misinterpretation of experimental results and affect treatment outcomes. We monitor dynamical changes of superficial cortical blood flow in the rat kidney following different routes of administration of the vasoconstrictor angiotensin II. Our analysis reveals the appearance of large scale oscillations of the blood flow caused by inhomogeneous intra organ drug distribution.