Open AccessHeartbeat OCT: in vivo intravascular megahertz-optical coherence tomography
Author(s) -
Tianshi Wang,
Tom Pfeiffer,
Evelyn Regar,
Wolfgang Wieser,
Heleen van Beusekom,
C.T. Lancée,
Geert Springeling,
Ilona Krabbendam,
Antonius F.W. van der Steen,
Robert Huber,
Gijs van Soest
Publication year - 2015
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.6.005021
Subject(s) - optical coherence tomography , heartbeat , undersampling , computer science , pullback , intravascular ultrasound , biomedical engineering , cardiac imaging , preclinical imaging , optics , fourier domain , image quality , computer vision , physics , medicine , in vivo , radiology , mathematics , geometry , computer security , microbiology and biotechnology , biology , image (mathematics)
Cardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality and the diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations of IV-OCT can be addressed by using an imaging system that we called "Heartbeat OCT", combining a fast Fourier Domain Mode Locked laser, fast pullback, and a micromotor actuated catheter, designed to examine a coronary vessel in less than one cardiac cycle. We acquired in vivo data sets of two coronary arteries in a porcine heart with both Heartbeat OCT, working at 2.88 MHz A-line rate, 4000 frames/s and 100 mm/s pullback speed, and with a commercial system. The in vivo results show that Heartbeat OCT provides faithfully rendered, motion-artifact free, fully sampled vessel wall architecture, unlike the conventional IV-OCT data. We present the Heartbeat OCT system in full technical detail and discuss the steps needed for clinical translation of the technology.