Open AccessCalibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography
Author(s) -
Kelly E. Michaelsen,
Venkataramanan Krishnaswamy,
Linxi Shi,
Srinivasan Vedantham,
Steven P. Poplack,
Andrew Karellas,
Brian W. Pogue,
Keith D. Paulsen
Publication year - 2015
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.6.004981
Subject(s) - tomosynthesis , imaging phantom , breast imaging , digital breast tomosynthesis , calibration , medicine , nuclear medicine , radiology , tomography , biomedical engineering , mammography , materials science , breast cancer , physics , cancer , quantum mechanics
Calibration of a three-dimensional multimodal digital breast tomosynthesis (DBT) x-ray and non-fiber based near infrared spectral tomography (NIRST) system is challenging but essential for clinical studies. Phantom imaging results yielded linear contrast recovery of total hemoglobin (HbT) concentration for cylindrical inclusions of 15 mm, 10 mm and 7 mm with a 3.5% decrease in the HbT estimate for each 1 cm increase in inclusion depth. A clinical exam of a patient's breast containing both benign and malignant lesions was successfully imaged, with greater HbT was found in the malignancy relative to the benign abnormality and fibroglandular regions (11 μM vs. 9.5 μM). Tools developed improved imaging system characterization and optimization of signal quality, which will ultimately improve patient selection and subsequent clinical trial results.