Open AccessSensitivity analysis aimed at blood vessels detection using interstitial optical tomography during brain needle biopsy procedures
Author(s) -
Julien Pichette,
Andréanne Goyette,
Fabien Picot,
M. Tremblay,
Gilles Soulez,
Brian C. Wilson,
Frédéric Leblond
Publication year - 2015
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.6.004238
Subject(s) - biopsy , brain tissue , histopathology , diffuse optical imaging , medicine , needle biopsy , tomography , biomedical engineering , blood volume , radiology , pathology , nuclear medicine , cardiology
A brain needle biopsy procedure is performed for suspected brain lesions in order to sample tissue that is subsequently analysed using standard histopathology techniques. A common complication resulting from this procedure is brain hemorrhaging from blood vessels clipped off during tissue extraction. Interstitial optical tomography (iOT) has recently been introduced by our group as a mean to assess the presence of blood vessels in the vicinity of the needle. The clinical need to improve safety requires the detection of blood vessels within 2 mm from the outer surface of the needle, since this distance is representative of the volume of tissue that is aspirated durirng tissue extraction. Here, a sensitivity analysis is presented to establish the intrinsic detection limits of iOT based on simulations and experiments using brain tissue phantoms. It is demonstrated that absorbers can be detected with diameters >300 μm located up to >2 mm from the biopsy needle core for bulk optical properties consistent with brain tissue.