Open AccessIn vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies
Author(s) -
Behrooz Zabihian,
Jessika Weingast,
Mengyang Li,
Edward Zhang,
Paul C. Beard,
Hubert Pehamberger,
Wolfgang Drexler,
B. Hermann
Publication year - 2015
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.6.003163
Subject(s) - optical coherence tomography , modality (human–computer interaction) , photoacoustic imaging in biomedicine , preclinical imaging , medicine , medical imaging , tomography , molecular imaging , dermatoscopy , optical imaging , diffuse optical imaging , biomedical engineering , radiology , pathology , computer science , in vivo , artificial intelligence , optics , melanoma , physics , microbiology and biotechnology , cancer research , biology
Vascular abnormalities serve as a key indicator for many skin diseases. Currently available methods in dermatology such as histopathology and dermatoscopy analyze underlying vasculature in human skin but are either invasive, time-consuming, and laborious or incapable of providing 3D images. In this work, we applied for the first time dual-modality photoacoustic and optical coherence tomography that provides complementary information about tissue morphology and vasculature of patients with different types of dermatitis. Its noninvasiveness and relatively short imaging time and the wide range of diseases that it can detect prove the merits of the dual-modality imaging system and show the great potential of its clinical use in the future.