Photoacoustic imaging of fluorophores using pump-probe excitation | Zendy

Julia Märk | Zendy; FranzJosef Schmitt | Zendy; Christoph Theiss | Zendy; Hakan Dortay | Zendy; Thomas Friedrich | Zendy; Jan Laufer | Zendy

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Photoacoustic imaging of fluorophores using pump-probe excitation

Author(s) -

Julia Märk,

FranzJosef Schmitt,

Christoph Theiss,

Hakan Dortay,

Thomas Friedrich,

Jan Laufer

Publication year - 2015

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.6.002522

Subject(s) - optics , photoacoustic imaging in biomedicine , materials science , excitation , photoacoustic spectroscopy , medical imaging , fluorescence , medicine , physics , radiology , quantum mechanics

A pump-probe technique for the detection of fluorophores in tomographic PA images is introduced. It is based on inducing stimulated emission in fluorescent molecules, which in turn modulates the amount of thermalized energy, and hence the PA signal amplitude. A theoretical model of the PA signal generation in fluorophores is presented and experimentally validated on cuvette measurements made in solutions of Rhodamine 6G, a fluorophore of known optical and molecular properties. The application of this technique to deep tissue tomographic PA imaging is demonstrated by determining the spatial distribution of a near-infrared fluorophore in a tissue phantom.

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