Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue | Zendy

Jason R. Maher | Zendy; Oranat Chuchuen | Zendy; Marcus H. Henderson | Zendy; SangHoon Kim | Zendy; Matthew T. Rinehart | Zendy; Angela D. M. Kashuba | Zendy; Adam Wax | Zendy; David F. Katz | Zendy

Open Access

Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue

Author(s) -

Jason R. Maher,

Oranat Chuchuen,

Marcus H. Henderson,

SangHoon Kim,

Matthew T. Rinehart,

Angela D. M. Kashuba,

Adam Wax,

David F. Katz

Publication year - 2015

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.6.002022

Subject(s) - optical coherence tomography , confocal , optics , analyte , materials science , diffuse optical imaging , raman spectroscopy , coherence (philosophical gambling strategy) , tomography , confocal microscopy , spectroscopy , biomedical engineering , chemistry , medicine , physics , quantum mechanics

We report the development of a combined confocal Raman spectroscopy (CRS) and optical coherence tomography (OCT) instrument (CRS-OCT) capable of measuring analytes in targeted biological tissues with sub-100-micron spatial resolution. The OCT subsystem was used to measure depth-resolved tissue morphology and guide the acquisition of chemically-specific Raman spectra. To demonstrate its utility, the instrument was used to accurately measure depth-resolved, physiologically-relevant concentrations of Tenofovir, a microbicide drug used to prevent the sexual transmission of HIV, in ex vivo tissue samples.

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