Open AccessDifferential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography
Author(s) -
Elena B. Kiseleva,
Mikhail Kirillin,
Felix I. Feldchtein,
I. Alex Vitkin,
Е. А. Сергеева,
Elena V. Zagaynova,
Streltzova Olga,
B Shakhov,
Ekaterina V. Gubarkova,
Natalia D. Gladkova
Publication year - 2015
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.6.001464
Subject(s) - optical coherence tomography , in vivo , pathology , medicine , differential diagnosis , tomography , preclinical imaging , radiology , biology , microbiology and biotechnology
Quantitative image analysis and parameter extraction using a specific implementation of polarization-sensitive optical coherence tomography (OCT) provides differential diagnosis of mucosal pathologies in in-vivo human bladders. We introduce a cross-polarization (CP) OCT image metric called Integral Depolarization Factor (IDF) to enable automatic diagnosis of bladder conditions (assessment the functional state of collagen fibers). IDF-based diagnostic accuracy of identification of the severe fibrosis of normal bladder mucosa is 79%; recurrence of carcinoma on the post-operative scar is 97%; and differentiation between neoplasia and acute inflammation is 75%. The promising potential of CP OCT combined with image analysis in human urology is thus demonstrated in vivo.