A new strategy for label-free detection of lymphoma cancer cells | Zendy

Nicola Martucci | Zendy; Ilaria Rea | Zendy; Immacolata Ruggiero | Zendy; Monica Terracciano | Zendy; Luca De Stefano | Zendy; Nunzia Migliaccio | Zendy; Camillo Palmieri | Zendy; Giuseppe Scala | Zendy; Paolo Arcari | Zendy; Ivo Rendina | Zendy; Annalisa Lamberti | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A new strategy for label-free detection of lymphoma cancer cells

Author(s) -

Nicola Martucci,

Ilaria Rea,

Immacolata Ruggiero,

Monica Terracciano,

Luca De Stefano,

Nunzia Migliaccio,

Camillo Palmieri,

Giuseppe Scala,

Paolo Arcari,

Ivo Rendina,

Annalisa Lamberti

Publication year - 2015

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.6.001353

Subject(s) - lymphoma , cancer , cancer detection , medicine , cancer research , pathology

In this paper, a new strategy for highly selective and sensitive direct detection of lymphoma cells by exploiting the interaction between a peptide and its B-cell receptor, has been evaluated. In particular, an idiotype peptide, able to specifically bind the B-cell receptor of A20 cells in mice engrafted with A20 lymphoma, has been used as molecular probe. The new detection technique has been demonstrated on a planar crystalline silicon chip. Coverage of 85% of silicon surface and detection efficiency of 8.5 × 10(-3) cells/μm(2) were obtained. The recognition strategy promises to extend its application in studying the interaction between ligands and their cell-surface receptors.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research