Open AccessUse of surface-enhanced Raman scattering as a prognostic indicator of acute kidney transplant rejection
Author(s) -
Jingmao Chi,
Zaw Thet,
Iliana Cardona,
Mujtaba Hosnain,
Neha Garg,
Heather R. Lefkowitz,
Peter Tolias,
Henry Du
Publication year - 2015
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.6.000761
Subject(s) - medicine , renal function , kidney , creatinine , biomarker , kidney transplantation , kidney transplant , raman scattering , kidney disease , biopsy , urology , pathology , radiology , raman spectroscopy , optics , chemistry , biochemistry , physics
We report an early, noninvasive and rapid prognostic method of predicting potential acute kidney dysfunction using surface-enhanced Raman scattering (SERS). Our analysis was performed on urine samples collected prospectively from 58 kidney transplant patients using a He-Ne laser (632.8 nm) as the excitation source. All abnormal kidney function episodes (three acute rejections and two acute kidney failures that were eventually diagnosed independently by clinical biopsy) consistently exhibited unique SERS spectral features in just one day following the transplant surgery. These results suggested that SERS analysis provides an early and more specific indication to kidney function than the clinically used biomarker, serum creatinine (sCr).