Open AccessLine-field parallel swept source MHz OCT for structural and functional retinal imaging
Author(s) -
Daniel Fechtig,
Branislav Grajciar,
Tilman Schmoll,
Cédric Blatter,
René M. Werkmeister,
Wolfgang Drexler,
Rainer A. Leitgeb
Publication year - 2015
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.6.000716
Subject(s) - optics , retinal , point spread function , optical coherence tomography , preclinical imaging , sensitivity (control systems) , spatial frequency , materials science , computer science , physics , ophthalmology , medicine , microbiology and biotechnology , electronic engineering , biology , in vivo , engineering
We demonstrate three-dimensional structural and functional retinal imaging with line-field parallel swept source imaging (LPSI) at acquisition speeds of up to 1 MHz equivalent A-scan rate with sensitivity better than 93.5 dB at a central wavelength of 840 nm. The results demonstrate competitive sensitivity, speed, image contrast and penetration depth when compared to conventional point scanning OCT. LPSI allows high-speed retinal imaging of function and morphology with commercially available components. We further demonstrate a method that mitigates the effect of the lateral Gaussian intensity distribution across the line focus and demonstrate and discuss the feasibility of high-speed optical angiography for visualization of the retinal microcirculation.