Open AccessIn vivo imaging of human photoreceptor mosaic with wavefront sensorless adaptive optics optical coherence tomography
Author(s) -
Kevin Wong,
Yifan Jian,
Michelle Cua,
Stefano Bonora,
Robert J. Zawadzki,
Marinko V. Sarunic
Publication year - 2015
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.6.000580
Subject(s) - adaptive optics , optical coherence tomography , wavefront , optics , deformable mirror , wavefront sensor , computer science , image quality , human eye , preclinical imaging , computer vision , physics , artificial intelligence , in vivo , image (mathematics) , microbiology and biotechnology , biology
Wavefront sensorless adaptive optics optical coherence tomography (WSAO-OCT) is a novel imaging technique for in vivo high-resolution depth-resolved imaging that mitigates some of the challenges encountered with the use of sensor-based adaptive optics designs. This technique replaces the Hartmann Shack wavefront sensor used to measure aberrations with a depth-resolved image-driven optimization algorithm, with the metric based on the OCT volumes acquired in real-time. The custom-built ultrahigh-speed GPU processing platform and fast modal optimization algorithm presented in this paper was essential in enabling real-time, in vivo imaging of human retinas with wavefront sensorless AO correction. WSAO-OCT is especially advantageous for developing a clinical high-resolution retinal imaging system as it enables the use of a compact, low-cost and robust lens-based adaptive optics design. In this report, we describe our WSAO-OCT system for imaging the human photoreceptor mosaic in vivo. We validated our system performance by imaging the retina at several eccentricities, and demonstrated the improvement in photoreceptor visibility with WSAO compensation.