Open AccessEngineering optically triggered droplets for photoacoustic imaging and therapy
Author(s) -
Jacob D. Dove,
Paul A. Mountford,
Todd W. Murray,
Mark A. Borden
Publication year - 2014
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.5.004417
Subject(s) - vaporization , photothermal therapy , materials science , fluence , microbubbles , laser , core (optical fiber) , optics , boiling point , nanoparticle , optoelectronics , nanotechnology , chemistry , composite material , ultrasound , physics , organic chemistry , acoustics
Liquid perfluorocarbon (PFC) droplets incorporating optical absorbers can be vaporized through photothermal heating using a pulsed laser source. Here, we report on the effect of droplet core material on the optical fluence required to produce droplet vaporization. We fabricate gold nanoparticle templated microbubbles filled with various PFC gases (C3F8, C4F10, and C5F12) and apply pressure to condense them into droplets. The core material is found to have a strong effect on the threshold optical fluence, with lower boiling point droplets allowing for vaporization at lower laser fluence. The impact of droplet size on vaporization threshold is discussed, as well as a proposed mechanism for the relatively broad distribution of vaporization thresholds observed within a droplet population with the same core material. We propose that the control of optical vaporization threshold enabled by engineering the droplet core may find application in contrast enhanced photoacoustic imaging and therapy.