Open AccessUltrahigh speed endoscopic optical coherence tomography for gastroenterology
Author(s) -
Tsung-Han Tsai,
HsiangChieh Lee,
Osman O. Ahsen,
Kaicheng Liang,
Michael G. Giacomelli,
Benjamin Potsaid,
Yuankai K. Tao,
Vijaysekhar Jayaraman,
Marisa Figueiredo,
Qin Huang,
Alex Cable,
James G. Fujimoto,
Hiroshi Mashimo
Publication year - 2014
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.5.004387
Subject(s) - optical coherence tomography , medicine , medical imaging , biomedical engineering , tomography , preclinical imaging , endoscopy , frame rate , nuclear medicine , radiology , materials science , optics , microbiology and biotechnology , in vivo , biology , physics
We describe an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor imaging catheter. The system had a 600 kHz axial scan rate and 8 µm axial resolution in tissue. Imaging was performed with a 3.2 mm diameter imaging catheter at 400 frames per second with a 12 µm spot size. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing upper and lower endoscopy. The use of distally actuated imaging catheters enabled OCT imaging with more flexibility, such as volumetric imaging in the small intestine and the assessment of hiatal hernia using retroflex imaging. The high rotational scanning stability of the micromotor enabled 3D volumetric imaging with micron scale volumetric accuracy for both en face OCT and cross-sectional imaging, as well as OCT angiography (OCTA) for 3D visualization of subsurface microvasculature. The ability to perform both structural and functional 3D OCT imaging in the GI tract with microscopic accuracy should enable a wide range of studies and enhance the sensitivity and specificity of OCT for detecting pathology.