Open AccessDetecting nanoparticles in tissue using an optical iterative technique
Author(s) -
Inbar Yariv,
Gilad Rahamim,
Elad Shliselberg,
Hamootal Duadi,
Anat Lipovsky,
Rachel Lubart,
Dror Fixler
Publication year - 2014
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.5.003871
Subject(s) - materials science , nanoparticle , penetration depth , nanorod , scattering , biomedical engineering , light scattering , optics , penetration (warfare) , biological tissue , colloidal gold , computer science , nanotechnology , physics , mathematics , medicine , operations research
Determining the physical penetration depth of nanoparticles (NPs) into tissues is a challenge that many researchers have been facing in recent years. This paper presents a new noninvasive method for detecting NPs in tissue using an optical iterative technique based on the Gerchberg-Saxton (G-S) algorithm. At the end of this algorithm the reduced scattering coefficient (µs'), of a given substance, can be estimated from the standard deviation (STD) of the retrieved phase of the remitted light. Presented in this paper are the results of a tissue simulation which indicate a linear ratio between the STD and the scattering components. A linear ratio was also observed in the tissue-like phantoms and in ex vivo experiments with and without NPs (Gold nanorods and nano Methylene Blue). The proposed technique is the first step towards determining the physical penetration depth of NPs.