Open AccessCharacterization of collagen in non-small cell lung carcinoma with second harmonic polarization microscopy
Author(s) -
Ahmad Golaraei,
Richard Cisek,
S. I. Kruglov,
Roya Navab,
Carolyn Niu,
Shingo Sakashita,
Kazuhiro Yasufuku,
MingSound Tsao,
Brian C. Wilson,
Virginijus Barzda
Publication year - 2014
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.5.003562
Subject(s) - microscopy , lung cancer , pathology , ex vivo , carcinoma , polarization (electrochemistry) , materials science , in vivo , lung , optics , medicine , biophysics , chemistry , biology , physics , microbiology and biotechnology
Polarization second harmonic microscopy was used for collagen imaging in human non-small cell lung carcinoma and normal lung tissues ex vivo and revealed significant differences in the nonlinear susceptibility component ratio, demonstrating potential use in cancer diagnosis.