Remote focal scanning optical projection tomography with an electrically tunable lens | Zendy

Lingling Chen | Zendy; Sunil Kumar | Zendy; Douglas J. Kelly | Zendy; Natalie Andrews | Zendy; Margaret J. Dallman | Zendy; P. M. W. French | Zendy; James McGinty | Zendy

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Remote focal scanning optical projection tomography with an electrically tunable lens

Author(s) -

Lingling Chen,

Sunil Kumar,

Douglas J. Kelly,

Natalie Andrews,

Margaret J. Dallman,

P. M. W. French,

James McGinty

Publication year - 2014

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.5.003367

Subject(s) - optics , lens (geology) , diffuse optical imaging , tomography , projection (relational algebra) , optical coherence tomography , optical tomography , computer science , materials science , physics , algorithm

We describe a remote focal scanning technique for optical projection tomography (OPT) implemented with an electrically tunable lens (ETL) that removes the need to scan the specimen or objective lens. Using a 4× objective lens the average spatial resolution is improved by ∼46% and the light collection efficiency by a factor of ∼6.76, thereby enabling increased acquisition speed and reduced light dose. This convenient implementation is particularly appropriate for lower magnifications and larger sample diameters where axial objective scanning would encounter problems with speed and stability.

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