Open AccessInvestigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography
Author(s) -
MengTsan Tsai,
Fu Chang,
ChengKuang Lee,
Cihun-Siyong Alex Gong,
Yuxiang Lin,
Jiann-Der Lee,
Chih-Hsun Yang,
Hao-Li Liu
Publication year - 2014
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.5.002009
Subject(s) - optical coherence tomography , speckle pattern , biomedical engineering , ultrasound , microbubbles , materials science , medicine , computer science , radiology , artificial intelligence
Focused ultrasound (FUS) can be used to locally and temporally enhance vascular permeability, improving the efficiency of drug delivery from the blood vessels into the surrounding tissue. However, it is difficult to evaluate in real time the effect induced by FUS and to noninvasively observe the permeability enhancement. In this study, speckle-variance optical coherence tomography (SVOCT) was implemented for the investigation of temporal effects on vessels induced by FUS treatment. With OCT scanning, the dynamic change in vessels during FUS exposure can be observed and studied. Moreover, the vascular effects induced by FUS treatment with and without the presence of microbubbles were investigated and quantitatively compared. Additionally, 2D and 3D speckle-variance images were used for quantitative observation of blood leakage from vessels due to the permeability enhancement caused by FUS, which could be an indicator that can be used to determine the influence of FUS power exposure. In conclusion, SVOCT can be a useful tool for monitoring FUS treatment in real time, facilitating the dynamic observation of temporal effects and helping to determine the optimal FUS power.