Open AccessSeparation of superficial and cerebral hemodynamics using a single distance time-domain NIRS measurement
Author(s) -
Alexander Jelzow,
Heidrun Wabnitz,
Ilias Tachtsidis,
Evgeniya Kirilina,
Rüdiger Brühl,
Rainer Macdonald
Publication year - 2014
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.5.001465
Subject(s) - functional near infrared spectroscopy , absorption (acoustics) , biomedical engineering , materials science , optics , diffuse optical imaging , near infrared spectroscopy , imaging phantom , time domain , homogeneous , sensitivity (control systems) , hemodynamics , nuclear magnetic resonance , computer science , mathematics , physics , medicine , computer vision , tomography , cognition , engineering , combinatorics , electronic engineering , psychiatry , prefrontal cortex
In functional near-infrared spectroscopy (fNIRS) superficial hemodynamics can mask optical signals related to brain activity. We present a method to separate superficial and cerebral absorption changes based on the analysis of changes in moments of time-of-flight distributions and a two-layered model. The related sensitivity factors were calculated from individual optical properties. The method was validated on a two-layer liquid phantom. Absorption changes in the lower layer were retrieved with an accuracy better than 20%. The method was successfully applied to in vivo data and compared to the reconstruction of homogeneous absorption changes.