Open AccessMeasurement of the total retinal blood flow using dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes
Author(s) -
Veronika Doblhoff-Dier,
Leopold Schmetterer,
Walthard Vilser,
Gerhard Garhöfer,
Martin Gröschl,
Rainer A. Leitgeb,
René M. Werkmeister
Publication year - 2014
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.5.000630
Subject(s) - optical coherence tomography , optics , doppler effect , blood flow , tomography , fourier transform , physics , materials science , medicine , radiology , quantum mechanics , astronomy
We present a system capable of measuring the total retinal blood flow using a combination of dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes and a fundus camera-based retinal vessel analyzer. Our results show a high degree of conformity of venous and arterial flows, which corroborates the validity of the measurements. In accordance with Murray's law, the log-log regression coefficient between vessel diameter and blood flow was found to be ~3. The blood's velocity scaled linearly with the vessel diameter at higher diameters (> 60 µm), but showed a clear divergence from the linear dependence at lower diameters. Good agreement with literature data and the large range and high measurement sensitivity point to a high potential for further investigations.