Open AccessUltrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina
Author(s) -
Zhuolin Liu,
Furu Zhang,
Kelvy Zucca,
Anant Agrawal,
Daniel X. Hammer
Publication year - 2022
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.462594
Subject(s) - optical coherence tomography , scanning laser ophthalmoscopy , adaptive optics , optics , retinal , computer science , retina , visualization , artificial intelligence , ophthalmology , medicine , physics
We describe the design and performance of a multimodal and multifunctional adaptive optics (AO) system that combines scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) for simultaneous retinal imaging at 13.4 Hz. The high-speed AO-OCT channel uses a 3.4 MHz Fourier-domain mode-locked (FDML) swept source. The system achieves exquisite resolution and sensitivity for pan-macular and transretinal visualization of retinal cells and structures while providing a functional assessment of the cone photoreceptors. The ultra-high speed also enables wide-field scans for clinical usability and angiography for vascular visualization. The FDA FDML-AO system is a powerful platform for studying various retinal and neurological diseases for vision science research, retina physiology investigation, and biomarker development.