Open AccessClot composition characterization using diffuse reflectance spectroscopy in acute ischemic stroke
Author(s) -
Simon Skyrman,
Gustav Burström,
Oskar Aspegren,
Draženko Babić,
Gerald W. Lucassen,
Erik Edström,
Fabian Arnberg,
Marcus Ohlsson,
Manfred Mueller,
Adrian Elmi-Terander,
Tommy Andersson
Publication year - 2022
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.458445
Subject(s) - medicine , stroke (engine) , diffuse reflectance infrared fourier transform , fibrin , occlusion , reflectivity , cardiology , pathology , radiology , chemistry , optics , mechanical engineering , biochemistry , physics , photocatalysis , engineering , immunology , catalysis
Acute ischemic stroke caused by large vessel occlusion is treated with endovascular thrombectomy, but treatment failure may occur when clot composition and thrombectomy technique mismatch. In this proof-of-concept study, diffuse reflectance spectroscopy (DRS) is evaluated for identification of clot composition ex vivo. DRS spectra and histology were acquired from 45 clot units retrieved from 29 stroke patients. DRS spectra correlated to clot RBC content, R= 81, p < .001, and could discriminate between RBC-rich and fibrin-rich clots, p < 0.001. Sensitivity and specificity for detection of RBC-rich clots were 0.722 and 0.846 respectively. Applied in an intravascular device, DRS could potentially provide intraprocedural information on clot composition that could increase endovascular thrombectomy efficiency.