Open AccessNoninvasive assessment of liver function reserve with fluorescent dosimetry of indocyanine green
Author(s) -
PeiChun Wu,
LunZhang Guo,
Shan Yu,
Ning Zeng,
Yucheng Liu,
Jia Yu,
Zhiming Zhang,
Ke Lu,
Liangyu Sun,
Chunfei Wang,
Yu-Han Chang,
Yin-Lin Lu,
Yu-Fang Shen,
Sheng Tai,
Yueh-Hsun Chuang,
Jaan Annie Ho,
Kai-Ping Huang,
YaoMing Wu,
Tzu-Ming Liu
Publication year - 2022
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.446749
Subject(s) - indocyanine green , dosimetry , medicine , blood sampling , liver function , nuclear medicine , hepatectomy , hepatocellular carcinoma , pathology , surgery , resection
Using in vivo multiphoton fluorescent dosimetry, we demonstrate that the clearance dynamics of Indocyanine Green (ICG) in the blood can quickly reveal liver function reserve. In normal rats, the ICG retention rate was below 10% at the 15-minute post-administration; While in the rat with severe hepatocellular carcinoma (HCC), the 15-minute retention rate is over 40% due to poor liver metabolism. With a 785 nm CW laser, the fluorescence dosimeter can evaluate the liver function reserve at a 1/10 clinical dosage of ICG without any blood sampling. In the future, this low-dosage ICG 15-minute retention dosimetry can be applied for the preoperative assessment of hepatectomy or timely perioperative examination.