Open AccessStudy of cerebrovascular reactivity to hypercapnia by imaging photoplethysmography to develop a method for intraoperative assessment of the brain functional reserve
Author(s) -
Maxim A. Volynsky,
Oleg V. Mamontov,
Anastasiia V. Osipchuk,
Valeriy V. Zaytsev,
Alexey Y. Sokolov,
Alexei A. Kamshilin
Publication year - 2021
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.443477
Subject(s) - photoplethysmogram , hypercapnia , hemodynamics , cerebral blood flow , medicine , cerebral perfusion pressure , perfusion , anesthesia , blood flow , perfusion scanning , cardiology , acidosis , computer science , filter (signal processing) , computer vision
Intraoperative assessment of cerebrovascular reactivity is a relevant problem of neurosurgery. To assess the functional reserve of cerebral blood flow, we suggest using imaging photoplethysmography for measuring changes in cortical perfusion caused by CO 2 inhalation. Feasibility of the technique was demonstrated in three groups of anesthetized rats ( n =21) with opened and closed cranial windows. Our study for the first time revealed that the hemodynamic response to hypercapnia strongly depends on the cranial state. However, it was shown that regardless of the direction of changes in local and systemic hemodynamics, the ratio of normalized changes in arterial blood pressure and cortical perfusion could be used as a measure of the cerebrovascular functional reserve.