Open AccessEffects of high intensity non-ionizing terahertz radiation on human skin fibroblasts
Author(s) -
Д. С. Ситников,
I. V. Ilina,
V. A. Revkova,
S. A. Rodionov,
Svetlana A. Gurova,
Rimma O. Shatalova,
Alexey V. Kovalev,
А. В. Овчинников,
O. V. Chefonov,
Mikhail Konoplyannikov,
Vladimir A. Kalsin,
Vladimir Baklaushev
Publication year - 2021
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.440460
Subject(s) - terahertz radiation , ionizing radiation , irradiation , human skin , non ionizing radiation , materials science , radiation , intensity (physics) , optics , electric field , biophysics , optoelectronics , biology , physics , nuclear physics , genetics , quantum mechanics
For the first time, the data have been obtained on the effects of high-intensity terahertz (THz) radiation (with the intensity of 30 GW/cm 2 , electric field strength of 3.5 MV/cm) on human skin fibroblasts. A quantitative estimation of the number of histone Н2АХ foci of phosphorylation was performed. The number of foci per cell was studied depending on the irradiation time, as well as on the THz pulse energy. The performed studies have shown that the appearance of the foci is not related to either the oxidative stress (the cells preserve their morphology, cytoskeleton structure, and the reactive oxygen species content does not exceed the control values), or the thermal effect of THz radiation. The prolonged irradiation of fibroblasts also did not result in a decrease of their proliferative index.