Three-dimensional dynamics optical coherence tomography for tumor spheroid evaluation | Zendy

Ibrahim Abd El-Sadek | Zendy; Arata Miyazawa | Zendy; Larina TzuWei Shen | Zendy; Shuichi Makita | Zendy; Pradipta Mukherjee | Zendy; Antonia Lichtenegger | Zendy; Satoshi Matsusaka | Zendy; Yoshiaki Yasuno | Zendy

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Three-dimensional dynamics optical coherence tomography for tumor spheroid evaluation

Author(s) -

Ibrahim Abd El-Sadek,

Arata Miyazawa,

Larina TzuWei Shen,

Shuichi Makita,

Pradipta Mukherjee,

Antonia Lichtenegger,

Satoshi Matsusaka,

Yoshiaki Yasuno

Publication year - 2021

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.440444

Subject(s) - optical coherence tomography , spheroid , tomography , dynamics (music) , biomedical engineering , microscopy , diffuse optical imaging , optics , computer science , physics , chemistry , medicine , biochemistry , acoustics , in vitro

We present a completely label-free three-dimensional (3D) optical coherence tomography (OCT)-based tissue dynamics imaging method for visualization and quantification of the metabolic and necrotic activities of tumor spheroid. Our method is based on a custom 3D scanning protocol that is designed to capture volumetric tissue dynamics tomography images only in a few tens of seconds. The method was applied to the evaluation of a tumor spheroid. The time-course viability alteration and anti-cancer drug response of the spheroid were visualized qualitatively and analyzed quantitatively. The similarity between the OCT-based dynamics images and fluorescence microscope images was also demonstrated.

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