Opto-chemical treatment for enhanced high-level disinfection of mature bacterial biofilm in a Teflon-based endoscope model | Zendy

Vân Nam Tran | Zendy; Periaswamy Sivagnanam Saravana | Zendy; Suhyun Park | Zendy; Van Gia Truong | Zendy; ByungSoo Chun | Zendy; Hyun Wook Kang | Zendy

Open Access

Opto-chemical treatment for enhanced high-level disinfection of mature bacterial biofilm in a Teflon-based endoscope model

Author(s) -

Vân Nam Tran,

Periaswamy Sivagnanam Saravana,

Suhyun Park,

Van Gia Truong,

ByungSoo Chun,

Hyun Wook Kang

Publication year - 2021

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.434047

Subject(s) - biofilm , endoscope , materials science , optics , biomedical engineering , nanotechnology , optoelectronics , medicine , bacteria , radiology , biology , genetics , physics

Medical societies and public health agencies rigorously emphasize the importance of adequate disinfection of flexible endoscopes. The aim of this work was to propose a novel opto-chemical disinfection treatment against Staphylococcus aureus grown in mature biofilm on Teflon-based endoscope channel models. Laser irradiation using near-infrared and blue wavelengths combined with a low concentration of chemical disinfectant induced both irreversible thermal denaturation and intercellular oxidative stress as a combined mechanism for an augmented antimicrobial effect. The opto-chemical method yielded a 6.7-log 10 reduction of the mature Staphylococcus aureus biofilms (i.e., approximately 1.0-log 10 higher than current requirement of standard treatment). The proposed technique may be a feasible disinfection method for mitigating the risk associated with infection transmission.

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