Open AccessCompressed sensing time-resolved spectrometer for quantification of light absorbers in turbid media
Author(s) -
Seva Ioussoufovitch,
David Jonathan Fulop Cohen,
Daniel Milej,
Mamadou Diop
Publication year - 2021
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.433427
Subject(s) - spectrometer , optics , materials science , spectroscopy , photon counting , absorption (acoustics) , imaging spectrometer , detector , scattering , light scattering , time resolved spectroscopy , optoelectronics , fluorescence , physics , quantum mechanics
Time-resolved (TR) spectroscopy is well-suited to address the challenges of quantifying light absorbers in highly scattering media such as living tissue; however, current TR spectrometers are either based on expensive array detectors or rely on wavelength scanning. Here, we introduce a TR spectrometer architecture based on compressed sensing (CS) and time-correlated single-photon counting. Using both CS and basis scanning, we demonstrate that-in homogeneous and two-layer tissue-mimicking phantoms made of Intralipid and Indocyanine Green-the CS method agrees with or outperforms uncompressed approaches. Further, we illustrate the superior depth sensitivity of TR spectroscopy and highlight the potential of the device to quantify absorption changes in deeper (>1 cm) tissue layers.