Towards in vivo photoacoustic imaging of vulnerable plaques in the carotid artery | Zendy

Jan-Willem Muller | Zendy; Roy van Hees | Zendy; Marc van Sambeek | Zendy; Pierre Boutouyrie | Zendy; Marcel C. M. Rutten | Zendy; Peter J. Brands | Zendy; Min Wu | Zendy; Richard G. P. Lopata | Zendy

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Towards in vivo photoacoustic imaging of vulnerable plaques in the carotid artery

Author(s) -

Jan-Willem Muller,

Roy van Hees,

Marc van Sambeek,

Pierre Boutouyrie,

Marcel C. M. Rutten,

Peter J. Brands,

Min Wu,

Richard G. P. Lopata

Publication year - 2021

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.430064

Subject(s) - carotid endarterectomy , medicine , photoacoustic imaging in biomedicine , carotid arteries , stenosis , vulnerable plaque , in vivo , radiology , preclinical imaging , endarterectomy , biomedical engineering , pathology , optics , biology , physics , microbiology and biotechnology

The main indicator for endarterectomy is the grade of stenosis, which results in severe overtreatment. Photoacoustic imaging (PAI) can provide patient-specific assessment of plaque morphology, and thereby vulnerability. A pilot study of PAI on carotid plaques in patients (n=16) was performed intraoperatively with a hand-held PAI system. By compensating for motion, the photoacoustic (PA) signal-to-noise ratio (SNR) could be increased by 5 dB in vivo. PA signals from hemorrhagic plaques had different characteristics compared to the signals from the carotid blood pool. This study is a key step towards a non-invasive application of PAI to detect vulnerable plaques.

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