In vivo measurement of the attenuation coefficient of the sclera and ciliary muscle | Zendy

Gabrielle Monterano Mesquita | Zendy; Disha Patel | Zendy; Yu-Cherng Chang | Zendy; Florence Cabot | Zendy; Marco Ruggeri | Zendy; Sonia H. Yoo | Zendy; Arthur Ho | Zendy; Jean–Marie Parel | Zendy; Fabrice Manns | Zendy

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In vivo measurement of the attenuation coefficient of the sclera and ciliary muscle

Author(s) -

Gabrielle Monterano Mesquita,

Disha Patel,

Yu-Cherng Chang,

Florence Cabot,

Marco Ruggeri,

Sonia H. Yoo,

Arthur Ho,

Jean–Marie Parel,

Fabrice Manns

Publication year - 2021

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.427286

Subject(s) - sclera , attenuation coefficient , attenuation , ciliary body , ophthalmology , in vivo , optics , ciliary muscle , anatomy , medicine , materials science , biomedical engineering , physics , biology , accommodation , microbiology and biotechnology

We acquired 1325 nm OCT images of the sclera and ciliary muscle of human subjects. The attenuation coefficients of the sclera and ciliary muscle were determined from a curve fit of the average intensity profile of about 100 A-lines in a region of interest after correction for the effect of beam geometry, using a single scattering model. The average scleral attenuation coefficient was 4.13 ± 1.42 mm -1 with an age-related decrease that was near the threshold for statistical significance (p = 0.053). The average ciliary muscle attenuation coefficient was 1.72 ± 0.88 mm -1 , but this value may be an underestimation due to contributions from multiple scattering. Overall, the results suggest that inter-individual variations in scleral attenuation contribute to variability in the quality of transscleral OCT images of the ciliary muscle and the outcome of transscleral laser therapies.

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