Open AccessIn vivo measurement of the attenuation coefficient of the sclera and ciliary muscle
Author(s) -
Gabrielle Monterano Mesquita,
Disha Patel,
Yu-Cherng Chang,
Florence Cabot,
Marco Ruggeri,
Sonia H. Yoo,
Arthur Ho,
Jean-Marie A. Parel,
Fabrice Manns
Publication year - 2021
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.427286
Subject(s) - sclera , attenuation coefficient , attenuation , ciliary body , ophthalmology , in vivo , optics , ciliary muscle , anatomy , medicine , materials science , biomedical engineering , physics , biology , accommodation , microbiology and biotechnology
We acquired 1325 nm OCT images of the sclera and ciliary muscle of human subjects. The attenuation coefficients of the sclera and ciliary muscle were determined from a curve fit of the average intensity profile of about 100 A-lines in a region of interest after correction for the effect of beam geometry, using a single scattering model. The average scleral attenuation coefficient was 4.13 ± 1.42 mm -1 with an age-related decrease that was near the threshold for statistical significance (p = 0.053). The average ciliary muscle attenuation coefficient was 1.72 ± 0.88 mm -1 , but this value may be an underestimation due to contributions from multiple scattering. Overall, the results suggest that inter-individual variations in scleral attenuation contribute to variability in the quality of transscleral OCT images of the ciliary muscle and the outcome of transscleral laser therapies.