Open AccessTreatment with LEDs at a wavelength of 642 nm enhances skin tumor proliferation in a mouse model
Author(s) -
Hyeyoon Goo,
SangJoon Mo,
Hyeong Ju Park,
Min Young Lee,
JinChul Ahn
Publication year - 2021
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.427205
Subject(s) - skin tumor , cancer research , dmba , proinflammatory cytokine , human skin , light emitting diode , medicine , skin cancer , dermatology , pathology , materials science , carcinogenesis , optoelectronics , immunology , cancer , biology , inflammation , genetics
Photobiomodulation (PBM) is attracting increased attention in the fields of dermatology and cosmetics. PBM with a variety of light parameters has been used widely in skin care, but can cause certain types of unwanted cells to proliferate in the skin; this can lead to skin tumors, such as papillomas and cancers. We constructed a mouse model of human skin tumors using DMBA as an initiator and TPA as a promoter, and confirmed that LEDs with a wavelength of 642 nm (red light) increased tumor size, epidermal thickness, and systemic proinflammatory cytokine levels. These results indicated that skin tumor cell proliferation may result from the use of 642 nm LEDs, suggesting the need for regulation of skin care based on LED light therapy.